Scientists from McMaster University and the University of Delhi in India have discovered and isolated the first live culture of the drug-resistant pathogen Candida auris from an animal, specifically from the ear canals of stray dogs.
The finding suggests pets could act as reservoirs for superbugs, potentially transmitting infections to humans.
First reported in Japan in 2009, C. auris is a type of yeast that has since spread all over the world.
The emerging fungus can cause persistent and severe infections and widespread outbreaks in hospitals. Antifungal medications often do not work against it and more than one in three patients with serious, invasive infections will die, according to some estimates.
The World Health Organization has declared it one of the world’s four “critical priority” fungal pathogens.
For a study published online in the Journal of Fungi, researchers tested skin and ear swab samples from 87 dogs in a Delhi shelter. The swabs were analyzed for bacteria and fungi cultures using routine diagnostic protocols for skin and ear infections.
Of those, 52 were strays already under intensive care for severe lesions from chronic skin diseases. The remaining 35 dogs were household pets treated for minor gastrointestinal and urinary infections. Their conditions were not related to the pathogen under study.
Researchers found evidence of C. auris within the ear canals of four of the animals with chronic skin infections.
“Dogs are common pets. Even though C. auris was only found in stray dogs in this study, there are many stray dogs in many parts of the world,” says Jianping Xu, a lead author on the paper and a professor in McMaster’s department of biology.
“These dogs could act as transmission vehicles for C. auris to reach other animals and humans.”
While fungi are significant pathogens for animals, no live culture of C. auris had previously been isolated.
A DNA analysis pointed to genomic similarities between some of the strains found in the dogs and those found in humans, providing further evidence that the spread of infection to other animals and humans is a risk.
“We need to be vigilant in the surveillance of dogs, other domesticated pets and wild animals in regions where C. auris is endemic,” says Xu, who is also an investigator with McMaster’s Global Nexus School for Pandemic Prevention & Response.
“While C. auris spreads easily from human to human, the route of transmission among animals or from animals to humans is much less clear and further investigation is required.”
When humans are infected with C. auris, inanimate objects in the environment are readily contaminated by the shedding of skin scales.
Because the yeast was found within the ear canal of the dogs, versus exposed skin, shedding in the immediate environment was reduced, containing the spread of infection.
C. auris has also been discovered on the surface of stored apples, in tidal marshes, in environments with extremely high salinity and, recently, in wastewater, suggesting it can survive in harsh conditions.